lichen planus
Oral lichen planus (OLP) is a common mucocutaneous disease and is thought to affect 0.5-1% of the world's population. This condition can affect either the skin or mucosa or both. It cause bilateral white striations, papules or plaques on the buccal mucosa, tongue, and gingival. Erythema, erosions and blisters may or may not be present. The relative risk for oral lichen planus is highest among those who smokes and chewes tobacco. Aetiology:- It is T-cell mediated auto-immune disease ↓ cytotoxic CD8 + T-cell trigger apoptosis of epithelial cells ↓ recognition of antigen associated with MHC (Major Histocompatibility Complex) ↓ activation of CD8 + T-cell ↓ trigger keratinocytes apoptosis ↓ activated CD8 + T-cell may release cytokines that attract additional lymphocytes into developing lesion. Clinical Features:- 1.) Affects female more (1.4:1). 2.) Probably occurs in older than 40 years. 3.) Skin lesion appears as s...